Treatment of Traumatic Brain Injury by Localized Application of Subatmospheric Pressure to the Site of Cortical Impact

Abstract

Each major war tends to have a signature injury , with traumatic brain injury (TBI) associated with the Iraq war (Operation Iraqi Freedom II and Operation Enduring Freedom) due to the high incidence of personnel injured by IED (improvised explosive devices). Our previous study in a rat model showed that Mechanical Tissue Resuscitation (MTR the controlled application of vacuum) to the cerebral cortex following a controlled cortical impact (CCI) injury reduces brain edema and the extent of injury, modulates metabolites in injured neuronal tissues, preserves neuronal tissue, and improves functional recovery. The large gyrencephalic brain of swine is similar to humans, thus a swine model of CCI injury and MTR treatment was evaluated for future human clinical applications. Year 3 goals were to determine the length of time between the initial injury event and efficacious application of vacuum.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2012
Accession Number
ADA580603

Entities

People

  • Michael Morykwas

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Afghanistan Conflict
  • Barometric Pressure
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Cerebral Cortex
  • Cerebral Edema
  • Explosive Devices
  • Hemorrhage
  • Improvised Explosive Devices
  • International Organizations
  • Iraqi-War
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • War

Readers

  • Trauma Surgery or Emergency Medicine.
  • Trauma or Military Medicine
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.