Estrogen-DNA Adducts as Novel Biomarkers for Ovarian Cancer Risk and for Use in Prevention

Abstract

The purpose of this research is to determine the association between ovarian cancer and (1) imbalances in estrogen metabolism that lead to higher levels of estrogen-DNA adducts in urine and/or (2) genetic polymorphisms in selected enzymes that metabolize estrogens. We completed this study as planned, demonstrating that estrogen metabolism is unbalanced in women diagnosed with breast cancer, as detected by the ratio of estrogen-DNA adducts to estrogen metabolites and conjugates (ratio = 91.4 43.1) compared to the balanced estrogen metabolism in the healthy controls (ratio = 24.7 12.7, p<0.0001). In addition women who were homozygous for the catechol-O-methyltransferase allele and the cytochrome P450 1B1 high activity allele had significantly increased DNA adduct ratios and increased odds of having ovarian cancer.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2013
Accession Number
ADA580742

Entities

People

  • Eleanor G. Rogan

Organizations

  • University of Nebraska Omaha

Tags

DTIC Thesaurus Topics

  • African Americans
  • Alcohol Consumption
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Databases
  • Department Of Defense
  • Education
  • Estrogens
  • Genetic Variation
  • Ligation
  • Metabolism
  • Metabolites
  • Neoplasms
  • Ovarian Cancer
  • Prostate Cancer
  • Risk Factors

Readers

  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology