Vesicant Therapeutics Collaborative Core Research Program

Abstract

This project at Johns Hopkins University serves as the In Vivo Delivery System Development Core of the Phase I Vesicant Therapeutics Collaborative Core Research Program (VT-CCRP). The Mission of this Core is focused on achieving Aim 3 of the Parent Grant at the USAMRICD. This Core aims to develop, evaluate, and downselect a nanotechnology-based system for in vivo RNAi delivery. This will be a critical component of validating therapeutic targets identified by the Target Discovery and In Vitro Validation Core in in vivo models of vesicant exposure. The Specific Aims are to evaluate nanotechnology-based delivery systems for RNAi delivery, to confirm delivery to target tissues in vivo, confirm knockdown of target in vivo, and to select the most effective delivery system for validation of targets in vivo. Two delivery systems, chitosan nanoparticles and PEG-PPA nanoparticles, will be under development and evaluation.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2012
Accession Number
ADA581049

Entities

People

  • Hai-Quan Mao

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Biomedical Engineering
  • Biomedical Research
  • Block Copolymers
  • Cell Line
  • Cells
  • Chemistry
  • Copolymers
  • Electron Microscopy
  • Epithelial Cells
  • Gel Electrophoresis
  • Light Scattering
  • Macrophages
  • Materials
  • Materials Science
  • Mrna
  • Polymeric Films

Fields of Study

  • Physics

Readers

  • Critical Infrastructure Protection in CBRN and WMD Threats.
  • Nanocomposite Materials Science
  • Research Science/Academic Research

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech