Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-induced Mild Traumatic Brain Injury

Abstract

We hypothesize that the biomechanical perturbations of the brain that yield blastinduced mTBI in injured warfighters can be recreated with reasonable fidelity in rats under carefully controlled experimental conditions, and that several of the characteristic sequelae of blast-induced mTBI observed clinically can be reproduced in a rodent injury model. In many, if not most circumstances yielding blast mTBI, brain injury results from a combination of blast overpressure (BOP) (i.e. primary blast) and head acceleration and/or impact (i.e. tertiary blast). The mTBI resulting from these combined insults may be fundamentally different from that seen from either insult alone.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2013
Accession Number
ADA581127

Entities

People

  • Joseph Long

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Neurodegeneration

Fields of Study

  • Biology

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Computational Modeling and Simulation