Development of Intra-Articular Drug Delivery to Alter Progression of Arthritis Following Joint Injury

Abstract

The work in this study addresses the development of post-traumatic osteoarthritis (PTOA) and seeks to develop a basis for future therapeutic interventions. Currently, the only disease-modifying treatment for articular fractures is surgical intervention. Estimates suggest as many as 12% of all symptomatic osteoarthritis patients are post-traumatic [1]. At the present time, the state of the art treatment for displaced articular fractures in weight bearing joints is surgical stabilization of the fracture with anatomic restoration of the articular surface when possible. Even with optimal treatment, displaced articular fractures in the lower extremity have a 10-20% incidence of post-traumatic osteoarthritis [2]. Currently, there is no pharmacological intervention, either systemically or locally, that has been shown to decrease the incidence of post-traumatic osteoarthritis. Growing evidence suggests that the inflammatory environment of the joint may also play a critical role in the development and progression of post-traumatic arthritis.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2013
Accession Number
ADA581150

Entities

People

  • Bridgette D. Furman
  • Farshid Guilak
  • Kelly A. Kimmerling
  • Steven A. Olson

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Arthritis
  • Biomedical Research
  • Bone Fractures
  • Cartilage
  • Department Of Defense
  • Dermatologic Agents
  • Histological Techniques
  • Inflammation
  • Inhibition
  • Instructions
  • Intervention
  • Joint Diseases
  • Lower Extremity
  • Statistical Analysis
  • Therapy
  • Tissues

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Systems Analysis and Design