Establishing the Mineral Apposition Rate of Heterotopic Ossification for Prevention of Recurrence

Abstract

In Year 1 of this grant the team established the necessary infrastructure and received full IRB approval. The investigators recruited 40% of their intended study population and demonstrated the ability to flurochrome label ectopic bone samples. Histological data is still being analyzed however; the first four patients of our study have mineral apposition rates (MAR) that are approximately 2x as rapid as non-pathological human bone (1.92 +/- 0.09 microns per day vs. 1.0 micron per day). Additionally, localized regions of bone demonstrated high metabolic growth, with MAR approaching 3.5 microns per day. Scanning electron microscopy has provided images of the varying stages of bone mineralization and highly vascular channels in HO. Salary support for the investigators has resulted in 2 peer-reviewed publications (1 accepted, 1 submitted) and grant W81XWH-12-2-0017 was acknowledged.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2013
Accession Number
ADA581156

Entities

People

  • Brad M Isaacson
  • Kyle Potter
  • Paul F Pasquina
  • Roy D. Bloebaum

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • Active Duty
  • Biomedical Research
  • Casualties
  • Data Analysis
  • Department Of Defense
  • Electronic Mail
  • Explosive Devices
  • Heterotopic Ossification
  • Histological Techniques
  • Images
  • Improvised Explosive Devices
  • Infrastructure
  • Institutional Review Board
  • Military Medicine
  • Osteogenesis
  • Photography
  • Residual Limbs

Readers

  • Aerial Delivery - Logistics and Supply Chain Management.
  • Clinical Trial Research.
  • Immunology and Pathology

Technology Areas

  • Microelectronics