Biomarker Discovery and Mechanistic Studies of Prostate Cancer Using Targeted Proteomic Approaches

Abstract

Our findings reveal that EMMPRIN immunoreactivity was primarily detected among the glandular epithelial cells; EMMPRIN levels progressively increased with increasing age of TRAMP mice (6-27 wks); with the highest detected in liver metastases. Quantitative analysis revealed that by 27-wks (an age exhibiting highly aggressive prostate tumor phenotype), EMMPRIN expression increased significantly (P=0.001). These results suggest that EMMPRIN may have diagnostic value in prostate cancer detection in advanced disease.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2012
Accession Number
ADA581284

Entities

People

  • Natasha Kyprianou

Organizations

  • University of Kentucky

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Cell Membrane
  • Cell Membrane Structures
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Confocal Microscopy
  • Cytoskeleton
  • Epithelial Cells
  • Intercellular Junctions
  • Neoplasms
  • Peptide Growth Factors
  • Prostate Cancer
  • Proteins
  • Proteomics

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Prostate Cancer Biology.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech