A Systems Biology Approach to Link Nuclear Factor Kappa B Activation with Lethal Prostate Cancer
Abstract
The 4% per year decline in the age specific prostate cancer mortality in the USA has come at the cost of treating a significant number of men who did not require therapy and are living with adverse events that diminish their quality of life. To identify patients with lethal prostate cancer we are deploying a systems biology approach to develop a risk scoring system. The systems biology approach is making use of the epidemiological, clinical, pathological and biological data that has implicated Nuclear factor kappa B (NF B) activation in the development lethal prostate cancer. Specifically, we hypothesize that lethal prostate cancer results from exogenous insults causing NF B activation which sets up a vicious cycle with further inflammatory insults and culminates in sustained NF B activation and carcinogenic changes in the microenvironment. This persistent activation results in progression of prostate cancer to a lethal disease. We aim to identify patients with lethal prostate cancer using a systems biology approach focused on the NF B pathway which will enable the construction of a risk scoring system to identify patients with localized but potentially lethal prostate cancer in need of therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2012
- Accession Number
- ADA581345
Entities
People
- Christopher Sweeney
Organizations
- Dana–Farber Cancer Institute