Novel High-Throughput Drug Screening Platform for Chemotherapy-Induced Axonal Neuropathy

Abstract

Taxol is an antineoplastic agent, which is used for the treatment of various cancer types such as breast, ovarian, lung, bladder, etc. It disrupts the microtubule assembly and accumulates in the dorsal root ganglion (DRG). The side effect of Taxol is peripheral neuropathy. DRG neurons are sensory nerve cells, and their cell bodies are bundled together lying outside of the spinal cord - ganglia. DRG neurons are accessible and convenient to harvest in embryonic animals and they survive well in culture.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2013
Accession Number
ADA581346

Entities

People

  • In H. Yang

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antineoplastic Agents
  • Biomedical Research
  • Cells
  • Chemotherapy
  • Department Of Defense
  • Electronic Mail
  • Information Operations
  • Neoplasms
  • Neurons
  • Neuropathy
  • Platforms
  • Side Effects
  • Spinal Cord
  • Throughput
  • Tissue Culture
  • Viability

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Neuroscience
  • Oncology