Development of Pantothenate Analogs That Can Treat Combat-Related Infections

Abstract

We solved the co-crystal structures of SaPanK with MT-190 and KpPanK with MT-183. Based on these structures, we synthesized 11 new compounds that fit to the Pan analog binding site of SaPanK or KpPanK. In addition, we showed qualitative bacterial killing efficiency of these 11 compounds by agar diffusion and their cytotoxicity to HepG2 cells. These new compounds will be the basis for further optimization to develop a novel class of narrow-spectrum antibiotics against the multidrug resistant strains of S. aureus and K. pneumoniae.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2013
Accession Number
ADA581554

Entities

People

  • Hee-won Park

Organizations

  • University of Toronto

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Biomedical Research
  • Cells
  • Crystal Structure
  • Crystallographic Techniques
  • Crystals
  • Demographic Cohorts
  • Diffraction
  • Diffusion
  • Efficiency
  • Electron Density
  • Escherichia Coli
  • Infection
  • Spectra
  • Staphylococcus Aureus

Fields of Study

  • Chemistry

Readers

  • Immunology
  • Military/Explosive Ordnance Disposal (EOD) Technology
  • Polymer Science and Technology