Corneal Protection for Burn Patients
Abstract
The overall goal of this research is to preserve vision of patients recovering from severe facial burns by providing an improved method to reduce development of corneal defects, inflammation, infection and opacification. Scope: To further improve and understand the properties of the degradation-resistant crosslinked amniotic membranes for treating cornea of burn patients that were produced in Years 1 and 2. Major findings: Identified membrane stiffness as a critical parameter for a successful cornea-protective membrane and quantitatively assessed this parameter. Monolayer crosslinked amnions showed low stiffness and excellent enzyme degradation resistance. Tri-layer membranes showed excellent enzyme degradation resistance but their high stiffness made eliminated them from further consideration. Showed that two of the three crosslinking methods to produce stable membranes also decreased the levels of a soluble pro-healing factor. Constructed an amnionencapsulated hydrogel lens with an improved enzyme resistance to be used to maintain hydration on the cornea surface of patients with peri-orbital scarring that prevents blinking.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2012
- Accession Number
- ADA581614
Entities
People
- Anthony J. Johnson
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine