Viral Immunotherapy to Eradicate Subclinical Brain Metastases
Abstract
To establish an animal model of breast cancer metastases to the brain and to use this model to demonstrate that anti-tumor host memory T-cells can be re-activated to enter and destroy early BM by viral infection of Her2-positive breast BM by a recombinant vesicular stomatitis virus (VSV), which liberates tumor antigens by viral oncolysis and induces acute inflammation in BM and CSF via the cytokine transgenes it carries and/or by adoptive transfer of cytotoxic, cytokine-producing natural killer (NK) cells capable of accumulating in smaller metastases of the brain.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2012
- Accession Number
- ADA581671
Entities
People
- Ira Bergman
Organizations
- University of Pittsburgh