Integrative Cardiac Health Project, Windber Research Institute
Abstract
The Integrative Cardiac Health Program (ICHP) aims to understand the complex interactions of numerous molecular components that characterize individuals or populations at risk for cardiovascular disease (CVD). We are working to identify molecular networks that define cardiovascular risk and correspond to lifestyle changes that may influence the trajectory of disease progression. Given the increasing trends of major CVD risk factors in the US military population and potentially devastating consequences on combat readiness, our efforts are directed to (1) better understanding the relationships of war stressors and CVD risk at the molecular level before onset of clinical disease, and (2) outcomes-based patient empowering lifestyle solutions to prevent disease. WRNMMC ICHP has developed a standardized and personalized lifestyle intervention program that has resulted in significant improvements in cardiovascular risk markers such as C-reactive protein (CRP), glucose, insulin, glycosylated hemoglobin, and lipids. Our previous research was the first to identify significant gene expression changes associated with an ultra-intensive lifestyle change program and to show that genetic variants at genes involved in lipid metabolism influence lipid response. We hypothesize that (1) identifying genetic influences on CVD and integrating information on dietary, behavioral, and lifestyle factors will provide important information on CVD risk reduction and (2) discovering new genes in previously associated pathways will reveal new molecular influences on cardiovascular risk reduction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2013
- Accession Number
- ADA581897
Entities
People
- Darrell L. Ellsworth
Organizations
- Windber Research Institute