Hypertonic Saline Dextran (HSD) in a Complex Military Injury - A Preclinical Study
Abstract
Recent data from current conflicts indicate that a significant proportion of severely injured military casualties result from explosive events. Although these are evacuated to surgical care as quickly as possible, extended evacuation is sometimes enforced. Significant logistical and potential physiological advantage might be attained by employing low volume resuscitation with hypertonic intravenous fluids. Current military practice for initial far-forward resuscitation involves hypotensive resuscitation with isotonic crystalloids. We have reported, based on a porcine model of severe haemorrhage that prolonged hypotensive resuscitation causes substantial physiological deterioration. A hybrid strategy (using 0.9% saline) of initial hypotensive (60 min) followed by normotensive resuscitation offered significant physiological benefit after haemorrhage alone and significantly better survival after combined haemorrhage and blast injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2010
- Accession Number
- ADA581932
Entities
People
- Sarah Watts