RNA Chimeras as a Gene Signature of Breast Cancer
Abstract
This project is set to test a hypothesis that breast cancer may express many RNA chimeras not only because there are fusion genes derived from chromosomal translocation but also because of abnormal trans-splicing of RNA transcripts. Many of these RNA chimeras may influence the behaviors of breast cancer via undiscovered mechanisms. We initially planned to establish the world s first comprehensive list of breast cancer specific fusion RNAs. However, last year we found out that our European competitor, Dr. Rolf I. Skotheim, had just submitted a patent application for making the same microarray chip (Patent application number: 20100279890; http://www.faqs.org/patents/app/20100279890#b). Several hundreds of fusion RNAs on their array list overlap with those on our list. While this latest development strengthens the importance of this project, it also forces us to forgo our task of building a similar chip for legal consideration. Since understanding of what chimeric RNAs are formed in breast cancer and how they are formed is still important for us to disclose mechanisms for breast cancer formation and progression, we continue to identify chimeric RNAs from different databases and have obtained several novel findings in the past year, as summarized below.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2013
- Accession Number
- ADA582144
Entities
People
- D. J. Liao
Organizations
- University of Minnesota