Understanding the Link Between Pregnancy and Breast Cancer
Abstract
The subject of this research is to understand the link between pregnancy and breast cancer. Pregnancy is associated with an immediate but transient increased risk of breast cancer in all women, with the risk peaking within 5 years after pregnancy. Breast cancer arising shortly after pregnancy are most frequently triple-negative breast cancers, which are characterized by a high rate of p53 mutation and by the activation of IGF signaling. The purpose of this research is to begin to understand the role of pregnancy in breast cancer by focusing on the p53-PAPPA-IGFII axis we have discovered and to test our hypothesis that Pregnancy-associated plasma protein A (PAPPA), a protease required for the activation of IGF signaling, is involved. The scope of this research is 1) to monitor the activation of IGF signaling and test the efficacy of anti-IGF therapy in our established triple-negative cell line model of pregnancy-dependent breast cancers, 2) to dissect the p53(MUT)-PAPP-A axis in pregnancy-associated mammary and 3) to determine whether PAPP-A expressing breast cancers are associated with increased serum levels of PAPP-A and IGF-II.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2013
- Accession Number
- ADA582282
Entities
People
- Doris Germain
Organizations
- Icahn School of Medicine at Mount Sinai