MALDI/Mass Spectrometry of Normal Appearing and Dystrophic Axons in Spinal Cord of Multiple Sclerosis (MS)
Abstract
Progressive myelopathy is the predominant feature of secondary and primary progressive MS. It is likely responsible for much of the disability seen in patients with MS. We postulated that the unremitting nature of the disorder is not likely to be due to loss of myelin, but rather a disorder of axons of the spinal cord. We therefore examined the protein profile of regions of normal appearing white matter between MS patients and controls using MALDI/spectrometry. Our preliminary studies show a difference in the signature of proteins in areas of normal appearing white matter between MS and controls. Our next step is to identify the nature of the proteins which are different between MS and controls.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2012
- Accession Number
- ADA582356
Entities
People
- Subramaniam Sriram
Organizations
- Vanderbilt University