Survival and Injury Outcome After TBI: Influence of Pre- and Post-Exposure to Caffeine

Abstract

Soldiers on active duty consume large amounts of caffeine, however little is known how chronic and acute caffeine use affects the outcome of traumatic brain injury (TBI). Data from our lab document that an acute dose of caffeine given after severe TBI in rats results in a dramatic reduction in mortality. The experiments presented herein provide a systematic analysis how acute versus chronic caffeine administered before or after TBI - modeled here in the rat lateral fluid percussion injury (FPI) model - affects survival and morbidity following TBI. We present data demonstrating that (i) chronic caffeine consumption is safe in regards to acute outcome parameters following TBI, (ii) default caffeine withdrawal after TBI is beneficial, whereas chronic caffeine consumption after TBI should be avoided, and (iii) a single bolus of caffeine after severe TBI can prevent lethal outcome, regardless of pre-injury caffeine consumption. We demonstrate that a wide dose range of caffeine is safe, with a moderate dose (equivalent to 2-3 cups of coffee for a human) was most effective.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA582477

Entities

People

  • Detlev Boison
  • Theresa Lusardi

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Cardiovascular System
  • Epilepsy
  • Health Services
  • Medical Personnel
  • Neurosciences
  • Seizures

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