Photonic Breast Tomography and Tumor Aggressiveness Assessment
Abstract
The tasks performed and the progresses made during the fourth year include the following: (1) carrying out research on the development of noninvasive near-infrared (NIR) diffuse optical imaging (DOI) approaches for the detection of breast tumors in the early stages of growth when they are more amenable to treatment; and (2) training of CCNY researchers at MSKCC in magnetic resonance spectroscopic imaging (MRSI) for the detection of lactate in tumors. The NIR optical imaging research involved the development of time reversal optical tomography (TROT) for imaging single absorbing and single scattering targets as a function of position, and two targets as a function of separation between them; and the adaptation and comparison of Principal Component Analysis (PCA) and Nonnegative Matrix Factorization (NMF) methods to the DOI problem and comparing them with previously developed OPTICA (optical tomography using independent component analysis). These approaches were demonstrated to be suited for detecting and locating small targets in tissue-simulating turbid media. MRSI investigation of lactate holds promise for assessment of tumor aggressiveness. We also have initiated the development of numerical algorithms for fluorescence tomography, since it has the potential to provide higher contrast as well as molecular and functional information through the use of exogenous fluorophores. A new research pre-proposal was developed and submitted to CDMRP 2011 BCRP Idea Award category for funding.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2012
- Accession Number
- ADA582694
Entities
People
- Binlin Wu
- F. B. Lin
- J. A. Koutcher
- M. Alrubaiee
- R. R. Alfano
- Swapan K. Gayen
Organizations
- City University of New York