Vaccines for Hantaviruses: Progress and Issues

Abstract

The Hantavirus genus of the family Bunyaviridae comprises more than 20 viruses, including several human pathogens. Hantaviruses are maintained in rodent reservoirs and are usually transmitted to humans in aerosols of rodent excreta. Oldworld rodents carry viruses that cause hemorrhagic fever with renal syndrome (HFRS) and new-world rodents carry viruses that cause hantavirus pulmonary syndrome (HPS). Four hantaviruses cause most cases of HFRS in Asia and Europe: Hantaan (HTNV), Seoul (SEOV), Puumala (PUUV) and Dobrava (DOBV) viruses. HPS- and HPS-causing hantaviruses were discovered in 1993 when an outbreak of severe respiratory distress of unknown etiology occurred in the USA. Most HPS cases result from infections with Sin Nombre virus in North America or Andes virus in South America [1,2].

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2012
Accession Number
ADA583184

Entities

People

  • Connie S Schmaljohn

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Bunyaviridae Infections
  • Disease Attributes
  • Diseases And Disorders
  • Governments
  • Infectious Diseases
  • Natural Disasters
  • North America
  • Public Health
  • Rodent Control
  • Rodents
  • South America
  • United States
  • Vaccines
  • Viruses
  • Volunteers

Readers

  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology