Development of Advanced Technologies for Complete Genomic and Proteomic Characterization of Quantized Human Tumor Cells

Abstract

This research proposal will provide important insights into cancer mechanisms and blood biomarkers to assess progression and stratification of human glioblastoma. We have collected several tumor specimens to date and have made excellent progress in establishing primary tumor cell cultures from individual tissue samples. These parental cell lines have successfully been used for the generation of quantized tumor cell populations for general molecular characterization, and for evaluating the effectiveness of drug candidates in targeting these cell populations. This program will significantly advance genomic, proteomic and single-cell technologies, which will be generally applicable to all cancer-based studies

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2013
Accession Number
ADA583639

Entities

People

  • Gregory Foltz

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biological Markers
  • Blood
  • Blood Proteins
  • Cell Line
  • Cells
  • Demographic Cohorts
  • Demography
  • Diseases And Disorders
  • Gene Expression
  • Health Services
  • Proteins
  • Proteomics
  • Stem Cells
  • Systems Approach
  • Transcriptomics

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Molecular and genetic basis of cancer.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology