Patient Characterization Protocols for Psychophysiological Studies of Traumatic Brain Injury and Post-TBI Psychiatric Disorders

Abstract

Psychophysiological investigations of traumatic brain injury (TBI) are being conducted for several reasons, including the objective of learning more about the underlying physiological mechanisms of the pathological processes that can be initiated by a head injury. Additional goals include the development of objective physiologically based measures that can be used to monitor the response to treatment and to identify minimally symptomatic individuals who are at risk of delayed-onset neuropsychiatric disorders following injury. Research programs studying TBI search for relationships between psychophysiological measures, particularly ERP (event-related potential) component properties (e.g., timing, amplitude, scalp distribution), and a participant s clinical condition. Moreover, the complex relationships between brain injury and psychiatric disorders are receiving increased research attention, and ERP technologies are making contributions to this effort. This review has two objectives supporting such research efforts. The first is to review evidence indicating that TBI is a significant risk factor for post-injury neuropsychiatric disorders. The second objective is to introduce ERP researchers who are not familiar with neuropsychiatric assessment to the instruments that are available for characterizing TBI, post-concussion syndrome, and psychiatric disorders. Specific recommendations within this very large literature are made. We have proceeded on the assumption that, as is typically the case in an ERP laboratory, the investigators are not clinically qualified and that they will not have access to participant medical records.

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Document Details

Document Type
Technical Report
Publication Date
Jul 22, 2013
Accession Number
ADA584022

Entities

People

  • Adele M. Gilpin
  • Alfonso M. Albano
  • Brenna M. Rosenberg
  • Christopher J. Cellucci
  • David O. Keyser
  • Dominic Nathan
  • Douglas Gibson
  • Kevin M. Toruno
  • Paul E. Rapp
  • Scott A. Wylie

Organizations

  • United States Army Medical Research and Development Command

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Brain
  • Brain Injuries
  • Cognition
  • Depression
  • Drug Abuse
  • Health Services
  • Medical Personnel
  • Psychiatry
  • Psychology
  • Traumatic Stress Disorder
  • Wounds And Injuries

Fields of Study

  • Medicine
  • Psychology

Readers

  • Aviation Safety Risk Assessment.
  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.