In Vitro Dermal Absorption of Insensitive Munitions Explosive 101 (IMX-101) and Components

Abstract

We studied in vitro dermal penetration of the newly developed munition, IMX-101 (Insensitive Munitions eXplosive) as whole composition and its individual components; 2-4-dinitroanisole (DNAN), 3-nitro-1,2,4,-triazole-5-one (NTO), and nitroguanidine (NQ) in static Franz diffusion cells. The penetration rate was calculated (micrograms/sq cm/hr) for each chemical. The analysis of absorbed chemical in the receptor fluid data showed that steady state of fluxes infinite dose (100 mg) of neat NTO, DNAN, and NQ were 338.2, 1.1, and 31.3 micrograms/sq cm/hr, respectively. The IMX-101 powder (100 mg) had a rate of flux for NTO, DNAN, and NQ were 135.9, 1.18, and 236.3 micrograms/sq cm/hr, respectively. The penetration of IMX-101 (10 mg) with Tyvek showed the penetration flux of NTO, DNAN, and NQ were 102.5, 1.9, and 46.4 micrograms/sq cm/hr, respectively. These estimated values in vitro human model will be used to evaluate health risk associated with dermal exposure.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2013
Accession Number
ADA584068

Entities

People

  • Gunda Reddy
  • Larry Williams
  • Wilfred C. Mccain

Organizations

  • United States Army Public Health Command

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Explosives
  • High Explosives
  • Insensitive Explosives
  • Liquid Chromatography
  • Material Degradation Processes
  • Materials
  • Materials Laboratories
  • Materials Science
  • Materials Testing
  • Military Research
  • Public Health
  • Steady State
  • United States

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