Combinatorial Therapy Approaches for NF2-Deficient Meningiomas

Abstract

The aim of our research is to find novel targeted therapy for NF2 patients to provide a new therapeutic option for meningiomas that includes the standard of care radiotherapy. We have successfully selected four small molecule compounds that preferentially inhibit NF2 mutant meningioma cells in vitro. These are FDA approved drugs that are safe for human use. We validated these drugs by using human cell lines and tested their ability to synergize with radiation. We have optimized the use of a CT-guided conformal radiation that can be tested in a meningioma mouse model. The findings from this research project will be valuable for future clinical trials, for testing combinatorial approaches to treat meningioma patients.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2013
Accession Number
ADA584501

Entities

People

  • Gilson S. Baia

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Cancer
  • Cell Line
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cultured Cells
  • Cytoskeleton
  • Diseases And Disorders
  • Enzyme Inhibitors
  • Gene Expression
  • Medical Personnel
  • Molecules
  • Oncology
  • Small Molecules
  • Stem Cells

Fields of Study

  • Medicine

Readers

  • Naval Engineering and Maritime Security
  • Oncology (Cancer Research).