T Cell Lipid Rafts and Complement Ligands for Diagnosis and Monitoring of SLE
Abstract
Ongoing complement activation is a feature of patients with systemic lupus erythematosus. Complement activation products deposit on the surface of cells and alter their function. During the course of this project we established that: 1) There is a significant difference in the distribution of complement proteins on T cells from SLE patients compared to other autoimmune diseases and normal individuals (C3d, C4d, CD59). 2) Complement deposition (C4d and C3d) is associated with SLE disease activity. 3) Complement deposition affect T cells function and decrease (or goes along with) Ca flux, IL- 2 production and cytotoxic activity. 4) C3d decorated T cells are prone to produce the proinflammatory cytokine IL-17 which may contribute to the inflammation-initiated tissue damage in SLE patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2011
- Accession Number
- ADA584898
Entities
People
- George C. Tsokos
Organizations
- Beth Israel Deaconess Medical Center