Yin and Yang of Heparanase in Breast Tumor Initiation
Abstract
Heparanase (HPR1) is an endoglycosidase that specifically degrades heparan sulfate proteoglycans, a main constituent on the cell surface and in the extracellular matrix and basement membrane. The role of heparanase in breast cancer tumorigenesis remains unclear. In particular, whether HPR1 enzymatic activity is required for its stimulatory effect on tumor growth and initiation are not fully understood. Here we report that the C-terminus of HPR1, which lacks the enzymatic activity, was able to accelerate breast cancer formation in a somatic breast cancer mouse model since mice infected with RCAS-Neu virus plus RCAS-8C (a vector encoding the C terminus of HPR1), developed breast cancer faster than that infected with RCAS-Neu plus RCAS-GFP control virus. Our results suggest that HPR1 may promote tumor growth independent of its enzymatic activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2013
- Accession Number
- ADA584964
Entities
People
- Xiulong Xu
Organizations
- Rush University