Convection-Enhanced Delivery (CED) in an Animal Model of Malignant Peripheral Nerve Sheath (MPNST) Tumors and Plexiform Neurofibromas (PN)

Abstract

Our experiments for the current study are ongoing. We have encountered several challenges in completing this. Work on this project was initially delayed by several months secondary to difficulty in obtaining regulatory approval from both our own IACUC and the DOD. Additionally, though we were able to establish and maintain an MPNST cell line suitable for our needs, we have been unable to maintain a cell line for benign plexiform neurofibroma. We have not been able to successfully establish the xenograft within the sciatic nerve. Using the MPNST cell line we were able to perform in vitro studies, comparing efficacy of erlotinib, rapamycin and imatinib in inhibition of cell proliferation and established that erlotinib is the most potent inhibitor for this particular cell line. The cell line we are using is aggressive and grows rapidly as a flank xenograft though we have not been able to successfully establish the xenograft within the sciatic nerve.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2012
Accession Number
ADA585101

Entities

People

  • Kaleb Yohay

Organizations

  • Cornell University

Tags

DTIC Thesaurus Topics

  • Alkynes
  • Biomedical Research
  • Cancer
  • Cell Line
  • Convection
  • Department Of Defense
  • Diseases And Disorders
  • Health Services
  • Neoplasms
  • Nerves
  • Nervous System
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Sciatic Nerve
  • Surgery
  • Therapy
  • Xenografts

Fields of Study

  • Biology
  • Medicine

Readers

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