Characterizing and Targeting Replication Stress Response Defects in Breast Cancer
Abstract
During the third year of this project, we have made significant progress in several of our proposed tasks. We found that TUSC4 is a potent tumor suppressor gene in breast cancer with an important function in stabilizing BRCA1 protein. In addition, we identified and validated AXL and Jag1 as two novel RSR-defect-specific membrane proteins and have successfully conjugated the antibodies against these two molecules to hollow gold nanoparticles. We also demonstrated the specific binding of these nanoparticles to RSR-defect breast cells in vitro and in vivo. Finally, we have identified and in vitro validated 5 top compound candidates that preferentially killed RSR-defect breast cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2013
- Accession Number
- ADA585104
Entities
People
- Chun Li
- Chun-jen Lin
- Hui Dai
- Ju-seong Lee
- Lili Gong
- Shiaw-Yih Lin
Organizations
- The University of Texas MD Anderson Cancer Center