Nutritional and Exercise Aspects of Prader-Willi Syndrome and Childhood Obesity
Abstract
Prader-Willi syndrome (PWS) is the best characterized genetic cause of obesity. To date, two major nutritional phases are identified. Exercise, a valuable tool for the management of obesity, is poorly understood and understudied in PWS. This project studies the nutritional and exercise aspects of PWS and childhood obesity. Preliminary Outcomes: Investigators identified seven distinct nutritional phases which consists of five major phases (phases 0 to 4) with phases 1 and 2 having two sub-phases (phases 1a, 1b, 2a, and 2b). In addition, serum ghrelin levels were significantly elevated in PWS individuals compared to normal sibling controls and individuals with early morbid obesity. Children with and without PWS completed maximal and submaximal aerobic exercise tests on a stationary bike. No major differences appear to exist in the hormonal and metabolic responses to exercise between children with and without PWS except for in 1) growth hormone (PWS do not show an exercise-induced response), and 2) testosterone (PWS demonstrate higher concentrations) Children with PWS respond to exercise with increases in IGF-1 independent of their GH deficiency. No outcomes can yet be reported on resistance exercise. The only outcomes reported at this time in response to resistance exercise are insulin, testosterone and free fatty acids. No major differences appear to exist in the response of these hormones or metabolites between those with PWS and other children.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2013
- Accession Number
- ADA585349
Entities
People
- Daniel A. Judelson
- Daniel J Driscoll
- Daniela A. Rubin
- Jie Weiss
- Michelle Moutappa
Organizations
- California State University, Fullerton