Nanomedicine for Early Disease Detection and Treatment

Abstract

A platform technology to prepare enzyme sensitive nanomedicine (ESNM), which integrates the imaging and treatment capability, has been developed to report and cure diseases. ESNM is prepared with multiple layers of polyelectrolytes, sequentially assembled on an inert gold nanoparticle, using alternating charged polymers. Potentially the release kinetics could be controlled by varying polyelectrolytes with different properties, such as length, ionic strength and bond stability. Upon incubation with cells, the assembled ESNMs are taken up efficiently. The tight packing and layered assembly of the quenched polyelectrolytes slow subsequent intracellular degradation, and

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA585392

Entities

People

  • Ching-Hsuan Tung

Organizations

  • Houston Methodist Research Institute

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Fabrication
  • Fluorescence
  • Health Services
  • Luminescence
  • Lymphocytes
  • Materials Processing
  • Materials Science
  • Metallic Nanoparticles
  • Molecules
  • Nanomedicine
  • Nanotechnology
  • Polymers
  • Stem Cells

Readers

  • Electrochemical Engineering/ Fuel Cell Technologies
  • Nanoscale Plasmonic Nanotechnology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech