NR2B-N-Methyl-D-Aspartate Receptors Contribute to Network Asynchrony and Loss of Long-Term Potentiation Following Mild Mechanical Injury In Vitro

Abstract

To understand how mechanical injury affects neural circuits, we (1) built a multi-scale stochastic integrate-and-fire model of network activity, (2) simulated an injured network, (3) predicted an important role for the NR2B-NMDA receptor in mediating network asynchrony, and 4) tested our predictions using in vitro stretch injury

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Document Details

Document Type
Technical Report
Publication Date
Aug 30, 2012
Accession Number
ADA586145

Entities

People

  • David F Meaney
  • Pallab K. Singh
  • Scott C. Ventre
  • Tapan P. Patel

Organizations

  • University of Pennsylvania

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Amplitude
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Culture Techniques
  • Department Of Defense
  • Dynamics
  • Information Operations
  • Mechanical Energy
  • Membrane Potentials
  • Military Research
  • Models
  • Multiscale Models
  • Scale Models
  • Simulations

Fields of Study

  • Biology

Readers

  • Computer Networking
  • Immunology
  • Neurotrauma and Rehabilitation Medicine.