Early Life Stress and Sleep Restriction as Risk Factors in PTSD: An Integrative Pre-Clinical Approach
Abstract
The project proposes a novel preclinical approach to study risk factors for and neurobiology of post-traumatic stress and depression. Why risk factors? Because PTSD is the only psychiatric disorder to which there is seemingly a clear etiological agent- a traumatic event that triggers it, most animal models of PTSD concentrate on what would constitute a trauma in the studied animals. However, because the majority of people exposed to traumatic experiences actually develop PTSD the exposure to the traumatic experience is necessary, but no a sufficient condition to induce disorder. We focus on both distal (childhood adversities) and proximal (sleep restriction) potential risk factors, with high relevance to soldiers. 1. To establish an effective animal model of PTSD that would consider the contribution of risk factors to the introduction of PTSD. 2. To examine the role of sleep restriction as a proximal risk factor of PTSD. 3. To establish the role of childhood adversities as a long-term risk factor in PTSD, particularly in association with sleep restriction. 4. To develop the model as a platform for pharmacological testing of novel targets for drug development.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2013
- Accession Number
- ADA586209
Entities
People
- Gal Richter-levin
Organizations
- University of Haifa