On the Pathophysiology of Cutaneous Cafe-au-lait Lesions in Neurofibromatosis and the Role of Keratinocyte and/or Fibroblast-Synthesized Cytokines

Abstract

Fibroblasts derived from the CALM lesion of NF1 are capable of inducing melanin synthesis by normal human melanocytes as demonstrated in both an in vitro and in vivo model system suggesting that undefined cytokines are synthesized by NF1 fibroblasts putatively resulting in CALM.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2007
Accession Number
ADA586812

Entities

People

  • Raymond E. Boissy

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anatomy
  • Biological Sciences
  • Biomedical Research
  • Biomolecules
  • Cells (Biology)
  • Culture Media
  • Cytokines
  • Department Of Defense
  • Electronic Mail
  • Epithelial Cells
  • Fibroblasts
  • Growth Factors
  • Information Operations
  • Neurofibromatosis
  • Pathophysiology
  • Proteins

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Molecular and Cellular Biology