Structural and Biochemical Studies of the Ovarian Tumor Domain

Abstract

BRCA1, or Breast Cancer Associated gene 1, is a breast and ovarian cancer-specific tumor suppressor. Recent research has shown that BRCA1, an E3 ubiquitin ligase, interacts in a complex that contains the human homologue of Ovarian Tumor (hOTU). Located within the OTU gene product is ~130 residue domain termed the Ovarian Tumor (OTU) domain that possesses deubiquitination activity.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2007
Accession Number
ADA587186

Entities

People

  • Troy E. Messick

Organizations

  • Wistar Institute

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Chemistry
  • Crystal Structure
  • Crystals
  • Cysteine
  • Data Processing
  • Molecules
  • Neoplasms
  • Ovarian Cancer
  • Proteins
  • Recognition
  • Three Dimensional

Fields of Study

  • Chemistry

Readers

  • Molecular Genetics
  • Molecular and genetic basis of cancer.