Cell Cycle Inhibitors as Breast Cancer Prevention Agents

Abstract

There is evidence from our own work and suggesting that histone H1 phosphorylation by cyclin E/CDK2 relaxes condensed heterochromatin, increasing vulnerability to DNA-damaging agents. We provide further evidence that inhibitors of cyclin E/CDK2 can reverse this vulnerability, and that H1 phospoorylation acts by disrupting H1 s association with another component of condensed heterochromatin, Heterochromatin Protein 1. This association may thus provide a relatively specific target for intervention to reduce DNA damage probability and the accompanying likelihood of cancer formation, which deserves further exploration.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2004
Accession Number
ADA587584

Entities

People

  • Ashby Morrison
  • Rafael Herrera

Organizations

  • Baylor College of Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Confocal Microscopy
  • Department Of Defense
  • Energy Transfer
  • Fibroblasts
  • Inhibitors
  • Mammary Glands
  • Microscopy
  • Neoplasms
  • Phase Transformations
  • Phosphorylation
  • Proteins
  • Vulnerability

Readers

  • Molecular and genetic basis of cancer.
  • Oncology