Metal Ion-Catalyzed Alcoholysis as a Strategy for the High Loading Destruction of Chemical Warfare Organophosphorus Agents
Abstract
Metal-catalyzed alcoholysis has proven to be an effective strategy for the rapid transformation of neutral reactive organophosphate esters of the phosphate, phosphonate, phosphorothioate, and phosphonothioate classes. This chemistry, using La(expn 3+) ( OMe)/Methanol as catalyst/solvent, applied to the V and G classes of chemical warfare agents, demonstrated extremely rapid transformation to low toxicity esters with load factors of ~30% for non-fluoride-releasing agents. Variation of the alcohol solvent is tolerated. Variations of the metal catalyst provide potential redress to the fluoride inhibition of the G agent class. These observations indicate that formulations based on mixed alcohol solvents combined with optimized metal catalysts for use in field decontamination, civilian security, and infrastructure scenarios provide a pathway for tuning the reaction media while retaining extremely rapid destruction kinetics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2013
- Accession Number
- ADA587633
Entities
People
- Alexei A. Neverov
- Andrea Tamer
- H. Dupont Durst
- R. S. Brown
Organizations
- Edgewood Chemical Biological Center