Glyco-Immune Diagnostic Signatures and Therapeutic Targets of Mesothelioma

Abstract

This project is funded in order to investigate immunoprofiles of serum anti-glycan antibodies recognizing Mesothelioma-derived aberrant glycans in human subjects and in animal models of Mesothelioma. This is accomplished using a one of a kind printed glycan array which has been developed by us at the New York University School of Medicine (NYU SoM) and has now been expanded by addition of 177 novel glycan probes, many of which are Mesothelioma-specific. It is expected that the results of these experiments will allow us to diagnose and prognosticate Mesothelioma earlier during its development. Results of our experiments using rat model of human Mesothelioma should also provide leads into the immuno-preventive and immunotherapeutic approaches to treatments of the military personnel of high-risk for this malignancy due to their potential long-term exposure to carcinogenic form of asbestos during their service.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2013
Accession Number
ADA588354

Entities

People

  • Harvey I Pass

Organizations

  • NYU Langone Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Asbestos
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Information Operations
  • Mesothelioma
  • Military Personnel
  • Neoplasms
  • New York
  • Printing
  • Schools
  • Universities

Readers

  • Immunology
  • Oncology
  • Superconducting Magnet Technology