Acceleration of Advanced CN Antidote Agents for Mass Exposure Treatments: DMTS

Abstract

Lethal rabbit CN poisoning models have been developed in our lab. Animals are monitored for oxy- and deoxy-Hb ratio changes by diffuse optical spectroscopy (DOS) and continuous wave near infrared spectroscopy (CWNIRS), breathed gas parameters, blood gas values and blood pressure during CN treatment and reversal. This year, stability and IM antidote administration studies have been completed using DMTS alone as the CN antidote, one of the 3 novel therapeutic agents under development with our collaborators. DMTS was dissolved in 15% polysorbate solution, and found to be stable for > 1 month. DMTS was successfully administered by IM injection, survival form <15% (controls) to >70%.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA588811

Entities

People

  • Matthew Brenner

Organizations

  • University of California, Irvine

Tags

DTIC Thesaurus Topics

  • Antidotes
  • Blood
  • Blood Flow
  • Blood Gases
  • Cardiovascular Physiological Phenomena
  • Combination Therapy
  • Continuous Waves
  • Gases
  • Heart Rate
  • Hemoglobin
  • Infrared Spectroscopy
  • Intramuscular Injections
  • Measurement
  • Poisoning
  • Spectroscopy
  • Survival
  • Therapy

Readers

  • Cardiovascular Physiology
  • Spectroscopy.
  • Toxicology/Environmental Toxicology