A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

Abstract

Our first-generation electronic microsystem is tested successfully in a rate model in both acute and chronic settings by recording neural spikes from one cortical region and subsequently driving microstimulation in a distant cortical region with a user-adjustable spike-stimulus time delay. Using a controlled cortical-impact device, we have successfully induced traumatic brain injury (TBI) in the caudal forelimb area (CFA) of the rat brain, sparing the rostral forelimb area (RFA) that is the target for implantation of the electronic microsystem. Behavioral assessments of reaching, retrieval of small food items, and locomotion demonstrate that deficits persist during the 5-week recovery period following injury. Further, an unprecedented, potent effect of activity-dependent stimulation (ADS) between the RFA and primary somatosensory forelimb area in brain-injured rats has been demonstrated by 5 days post-lesion.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2011
Accession Number
ADA589246

Entities

People

  • Pedram Mohseni

Organizations

  • Case Western Reserve University

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Algorithms
  • Amplifiers
  • Application-Specific Integrated Circuits
  • Brain Injuries
  • Capacitors
  • Computer Science
  • Computers
  • Converters
  • Department Of Defense
  • Digital Signal Processing
  • Electrical Engineering
  • Energy Consumption
  • Fabrication
  • Frequency
  • Nervous System
  • Signal Processing
  • Waveforms

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Microelectronics