Alterations of the Bone Marrow Microenvironment Contribute to Prostate Cancer Skeletal Metastasis

Abstract

The purpose of this postdoctoral training grant was to provide the PI with opportunity to explore the metastatic bone microenvironment under the supervision of the mentor, Dr. Laurie McCauley, at the University of Michigan. The research plan of this proposal was to test a hypothesis that alternations of bone marrow microenvironment contribute to metastatic prostate cancer growth in bone. The specific aims were designed to investigate the contribution of hematopoietic cellular compartment in the bone marrow to the development of prostate cancer skeletal metastasis. This study demonstrated that alternations induced by cyclophosphamide, one of the mowt widely used chemotherapeutic drugs, enhanced bone metastasis in a prostate cancer animal model. Furthermore, this study showed tha the pro-metastatic effects of cyclophosphamide were significantly reversed by suppression of CCl2, which suggests the causal role of bone marrow myeloid lineage cell expansion in promoting metastasis in the mouse model used in this study.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2012
Accession Number
ADA589269

Entities

People

  • Serk I. Park

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Blood
  • Bone And Bones
  • Bone Diseases
  • Bone Marrow Cells
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Leukocytes
  • Lymphocytes
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Stem Cells

Readers

  • Oncology (Cancer Research).