The Cytoplasm Translocation of the Androgen Receptor Cofactor p44 as a Target for Prostate Cancer Treatment

Abstract

We determined the dosage reimen for adiministration of identified chemical compounds and found that identified compounds inhibited androgen-dependent growth of prostate tumors in nude mice. The growth inhibition is associated with suppression of p44 cytoplasm tranportation. We also found that the nuclear exclusion signal (NES1) of p44 does not function in the differentiated prostate epithelial cells. This finding reveals a novel mechanism by which p44 subcellular tranlocation is determined and regulated during prostate development and prostate tumorigenesis.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA589529

Entities

People

  • Zhengxin Wang

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Bodies
  • Body Weight
  • Cells
  • Chemical Compounds
  • Cytoplasm
  • Epithelial Cells
  • Inhibition
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Tissues
  • Transport Ships

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Prostate Cancer Biology.