Serum Antibody Biomarkers for ASD
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in communication (verbal and nonverbal), social interactions, and stereotyped behaviors/interests. The etiology of ASD is not well understood, though it likely involves both genetic and environmental factors. Immune system dysfunction has been reported in ASD in many studies. Systemic immunologic alterations in autistic individuals often have been associated with autoimmunity; in particular, the generation of antibodies reactive against brain and CNS proteins. The goal of this grant proposal is to identify serum antibody biomarkers for ASD using a novel combinatorial peptoid library that has been successful for the identification of antibody biomarkers for Alzheimer s disease. An ASD blood biomarker would be very useful for early identification and targeted therapeutic intervention. During Year-1 of the grant we have (1) collected serum samples from additional male typically developing (TD) and unaffected sibling (US) controls; (2) collected serum samples from additional female TD and US controls; (3) made peptoid libraries; and (4) screened libraries for peptoids using pooled serum samples from male ASD, and male TD controls.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA589530
Entities
People
- Dwight German
Organizations
- University of Texas at Dallas