Structural, Morphological, and Functional Correlates of Corneal Endothelial Toxicity Following Corneal Exposure to Sulfur Mustard Vapor

Abstract

Sulfur mustard (SM) is a highly reactive vesicant that causes severe ocular injuries. Following exposure to moderate or high doses, a subset of victims develops a chronic injury known as mustard gas keratopathy (MGK) involving a keratitis of unknown etiopathogenesis with secondary keratopathies such as persistent epithelial lesions, corneal neovascularization, and progressive corneal degeneration. This study was designed to determine whether SM exposure evokes acute endothelial toxicity and to determine whether endothelial pathologies were specifically observed in MGK corneas as opposed to healed corneas.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA589556

Entities

People

  • Angie Adkins
  • Elliot J Glotfelty
  • James S. Hughes
  • Kaylie Tuznik
  • Marian Nelson
  • Megan Lyman
  • Patrick M. McNutt
  • Tracey Hamilton

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Boundaries
  • Cell Physiological Processes
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Confocal Microscopy
  • Cornea
  • Corneal Diseases
  • Electron Microscopes
  • Electron Microscopy
  • Epithelium
  • Eye
  • Microscopes
  • Microscopy
  • Mustard Agents
  • United States

Fields of Study

  • Medicine

Readers

  • Acoustics.
  • Analytical Chemistry
  • Immunology and Pathology