Mechanisms of Mitochondrial Dysfunction in Autism

Abstract

The purpose of this study is to define correlations between indices of brain dysfunction, such as functional MRI (fMRI) and the neuropsychological testing abnormalities, with oxidative phosphorylation (OXPHOS) defects in children with autism spectrum disorders (ASD). This study is an essential step in identifying such a phenotypic subtype, being able to perform large-scale epidemiological studies using more widely available measures, and ultimately being able to implement clinical trials for new pharmaceutical agents emerging for treatment of the OXPHOS defects which could significantly improve the functioning of children with ASD with this defect. Data acquisition is ongoing and larger numbers of subjects are needed before meaningful conclusions can be drawn from the study.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2013
Accession Number
ADA589590

Entities

People

  • Diana Robins
  • John Shoffner
  • Robin Morris
  • Tricia King

Organizations

  • Georgia State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abnormalities
  • Acquisition
  • Autism
  • Biomedical Research
  • Cell Line
  • Cells
  • Clinical Trials
  • Cytoplasmic Structures
  • Data Acquisition
  • Data Analysis
  • Data Processing
  • Diseases And Disorders
  • Dysfunction
  • Human Behavior
  • Information Science
  • Metabolic Diseases
  • Statistical Analysis

Fields of Study

  • Medicine

Readers

  • Instructional Design and Training Evaluation.
  • Molecular and Cellular Biology
  • Neuroscience