Nrf2: A Novel Biomarker of Disease Severity and Target for Therapeutic Intervention in Multiple Sclerosis
Abstract
It has been suggested that the molecules capable of inducing endogenous antioxidant enzymes through the activation of the Nrf2/ARE pathway may be highly effective in therapeutic and chemopreventive strategies designed to inhibit pathological processes underlying MS lesion formation. Under this proposal we have employed a successful strategy to isolate and characterize one of such compound Triterpenoid from natural plant resources. By applying diversity oriented synthesis we have created several unique triterpenoid structures which will enable careful dissection of the Nrf2-dependent and independent pathways mediating neuroprotection and inflammation and will define a novel class of potent and effective therapeutic and chemopreventive agents for multiple sclerosis. The following progress has been made within the first year of this project: 1) Successful large scale (in gram quantity) isolation of Bryonolic acid from zucchini plant (Cucurbita pepo L.) roots. 2) Characterized the activity of isolated Bryonolic acid 3) Applied Diversity Oriented Synthesis to Bryonolic acid to rearrange skeletal structure 4) Analyzed the specificity and activity of skeletally diverse triterpenoids in vivo and in vitro.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA589739
Entities
People
- John Letterio
Organizations
- Case Western Reserve University