Regulation and Function of Cytokines That Predict Prostate Cancer Metastasis
Abstract
We identified biomarkers that help distinguish aggressive disease from those that do not progress following prostatectomy. Specifically, CX3CL1 and IL15 were identified to be downregulated in subjects that developed recurrent prostate cancer. Conversely, CCL4 was upregulated patients with recurrent disease. The role of Stat3 activation and p53 intracellular signaling downstream of these cytokines commonly seem to differentialy regulate invasion and sensitivity adhesion dependent survival. Further, these two cytokines similarly reduced adhesion of LNCaP cells to collagen I. However, sensitivity to aniokis was dramatically induced in the same cells by CX3CL1 and IL15. This data support the clinical observation of recurrent free subjects having greater expression of CX3CL1 and IL15. Further, these factors may even serve as anti-metastatic mediators, despite their limited effects on tumor cell proliferation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA590468
Entities
People
- Neil A. Bhowmick
Organizations
- University of California