Role of Sleep Deprivation in Fear Conditioning and Extinction: Implications for Treatment of PTSD

Abstract

PTSD is a growing concern for both active duty personnel and Veterans. Fear conditioning is implicated in the development of PTSD, while successful acquisition, consolidation, and recall of extinction memory are implicated in both the natural reduction of initial PTSD symptoms and as the mechanism underlying the most successful treatment for PTSD, Prolonged Exposure. In animal models, sleep deprivation has been shown to impair extinction memory, although this has never been directly tested in humans. This project is the first to examine the role of sleep and sleep loss in acquisition, consolidation, and generalization of extinction memory in humans.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA590493

Entities

People

  • Sean P. Drummond

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Active Duty
  • Biomedical Research
  • Data Processing
  • Department Of Defense
  • Deprivation
  • Diseases And Disorders
  • Extinction
  • Information Operations
  • Learning
  • Medical Personnel
  • Mental Disorders
  • Nervous System Diseases
  • Neurologic Manifestations
  • Sleep Deprivation

Fields of Study

  • Psychology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Neuroscience