Mechanism and Therapy for the Shared Susceptibility to Migraine and Epilepsy after Traumatic Brain Injury (TBI)
Abstract
Our proposal studies the natural history and mechanisms of increased brain excitability leading to migraine and epilepsy after traumatic brain injury. In the 18 months since this grant was funded, we have performed experiments spanning nearly the whole range of our proposed work. The most important milestones in this project year have been: 1. Successful implementation of very challenging post-TBI in vivo two-photon imaging and in vivo whole cell recording. 2. Identification of novel TBI-specific phenotypes from our in vivo whole cell recordings. 3. Resolution of technical difficulties in telemetry recordings, and recording of both acute and chronic datasets. 4. Progressive implementation of histological techniques, with confirmation thus far of expected TBI phenotypes. 5. Implementation of post- TBI pain behavior measurements.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA590494
Entities
People
- Ed Dudek
- Jorge M. Mendez
- K. C. Brennan
- Punam Sawant
- Wendy Pouliot
Organizations
- University of Utah