Prostate Cancer Detection Using High-Spatial Resolution MRI at 7.0 Tesla: Correlation with Histopathologic Findings at Radical Prostatectomy
Abstract
This study aims to develop high spatial-resolution prostate MRI at 7.0T. During the earlier phase of our study, we performed technical development and optimization of the necessary hardware and software to achieve standard T2-weighted imaging for 7.0T prostate MRI. Specifically, we implemented a novel surface coil array in conjunction with optimization of turbo-spin echo T2-weighted sequences to achieve high spatial-resolution high SNR images. This system employed two transmit-receive elements and six receive-only elements, avoiding parallel transmission and RF shimming, thereby achieving a much simpler design than has been explored by other groups for 7T prostate MRI. In the present study period, this system was applied in two men with prostate cancer prior to prostatectomy. In both of these patients, 7T T2WI readily demonstrated dominant peripheral zone tumors with excellent visual correspondence with pathologic findings from prostatectomy. This work is valuable given that while new 7T systems offer the possibility of imaging prostate cancer using contrast mechanisms that have not been reliably performed at 1.5T and 3T, such as arterial-spin labeling and multinuclear imaging, it is necessary to first be able to perform standard MR sequences at diagnostic quality at 7T. We have demonstrated such feasibility in our current study, thus creating opportunity to pursue integration of novel techniques into a potential 7T clinical MR examination.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA590561
Entities
People
- Andrew B. Rosenkrantz
Organizations
- New York University