Toxicity Evaluation of Engineered Nanomaterials (Phase 1 Studies)
Abstract
This project entitled "Toxicity Evaluation of Engineered Nanomaterials" focuses toward developing a fundamental understanding of the interaction of nanomaterials with biological molecules that can be exploited to predict the toxicological effects of engineered nanomaterials in relation to occupational human exposure. Nanoscale science is, by nature, an interdisciplinary venture with enormous implications and diverse DoD applications in areas such as medicine, energy, materials, communications, and electronics. The overarching goal of this effort was to develop a fundamental understanding of nanostructure-cellular interactions, and how these relationships are affected by nanostructure composition, size, and shape. The work focused on establishing the fundamental mechanisms of biological interactions of engineered nanomaterials, including toxicities arising from the physicochemical properties uniquely associated with nanoscale structures. This knowledge will not only help to improve nanomaterials' safety strategies for the protection of both human and environmental occupational health, but also help develop advanced nanobiotechnologies for both defense and civilian applications.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2012
- Accession Number
- ADA590646
Entities
People
- Amanda Schrand
- Bradley Stacy
- Carol Garrett
- Christin Grabinski
- David H Ellis
- Jonathan Lin
- Michelle Kiyota
- Monita Sharma
- Nicole Schaeublin
- Saber Hussain
Organizations
- Air Force Research Laboratory